A novel in vitro survival assay of small intestinal stem cells after exposure to ionizing radiation.

Motohiro Yamauchi,Kensuke Otsuka,Hisayoshi Kondo,Nobuyuki Hamada,Masanori Tomita,Masayuki Takahashi,Satoshi Nakasono,Toshiyasu Iwasaki,Kazuo Yoshida

Journal of Radiation Research（2014）

引用 19|浏览4

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摘要

The microcolony assay developed by Withers and Elkind has been a gold standard to assess the surviving fraction of small intestinal stem cells after exposure to high (≥8 Gy) doses of ionizing radiation (IR), but is not applicable in cases of exposure to lower doses. Here, we developed a novel in vitro assay that enables assessment of the surviving fraction of small intestinal stem cells after expo...

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关键词

small intestinal stem cells,ionizing radiation,survival assay,Lgr5,in vitro culture,organoid

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