Identification, by RT-PCR, of eight novel I₂-conotoxins from the worm-hunting cone snails Conus brunneus, Conus nux, and Conus princeps from the eastern Pacific (Mexico).

R Zamora-Bustillos,R Rivera-Reyes,M B Aguilar,E Michel-Morfín,V Landa-Jaime,A Falcón,E P Heimer

Peptides（2014）

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摘要

•Precursors of I-conotoxins were identified from C. brunneus, C. nux, and C. princeps.•The precursors belong to the I2 gene superfamily.•The predicted mature toxins share high sequence identity among them.•The mature toxins might target voltage-gated potassium channels.

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关键词

Conus brunneus,Conus nux,Conus princeps,I-conotoxin,cDNA cloning,Conotoxin precursor

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