Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study.

Athanasios Koutsos,Kim G Jackson,Stacey Lockyer,Andrew Carvalho-Wells,Anne M Minihane,Julie A Lovegrove

Cytokine（2014）

Cited 5|Views10

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Abstract

•The effect of diet and genotype on inflammatory response was explored in humans.•Cytokine production was not affected by apolipoprotein E (APOE) genotype.•TNF-α concentration significantly increased after a high saturated fat diet.•IL-10 concentration was significantly higher after a low fat diet.•The amount and type of dietary fat modulated cytokine production.

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Key words

APOE,BMI,CHO,CRP,CVD,DHA,GM-CSF,HSF,ICAM-1,IFN,IL,LDL-C,LF,LPS,MUFA,NF-κB,PUFA,SFA,SNP,TNF-α,VCAM-1,WBC

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