Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates.
Behavioural Brain Research(2014)
Abstract
•α-Synuclein fibrils and/or oligomers were given intranasally for 14 days in mice.•Combined oligomers+fibrils caused rigidity and locomotor impairment.•Nigral DA and it's metabolite levels increased after oligomer+fibril treatment.•α-Synuclein fibrils enhanced DA levels in the substantia nigra.•DA turnover (DOPAC/DA but not HVA/DA ratio) was augmented after fibril treatment.
MoreTranslated text
Key words
Rodent model,α-synuclein oligomers,Fibrils,Behavior,Dopamine neurochemistry
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined