RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7

Transcription termination correlates with the loss of Tyr1 phosphorylation from the C-terminal domain (CTD) of Rpb1, an event thought to be necessary for the recruitment of termination factors. The phosphatase Glc7, an integral component of the cleavage-and-polyadenylation factor (CPF), is now shown to dephosphorylate Tyr1 and to contribute to termination in vivo .