乙醇代谢酶类基因多态性及环境暴露在结直肠癌发生中交互作用的单纯病例研究
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi(2013)
Abstract
目的 研究环境因素与乙醇脱氢酶1B(ADH1B)rs1229984、乙醛脱氢酶2(ALDH2)rs671、细胞色素P4502E1 (CYP2E1)rs1329149交互及基因-基因之间交互在结直肠癌发生中的作用,分析该3个基因位点对结直肠癌发展的影响.方法 采用单纯病例研究调查472例结直肠癌患者环境暴露情况和病理分期,用Sequenom MassARRA系统检测ADH 1B (rs 1229984)、ALDH2(rs671)、CYP2E1 (rs1329149)的基因型,应用非条件logistic回归分析ADH1B、ALDH2、CYP2E1基因多态性与环境因素及基因-基因之间的交互作用,采用x2检验及非条件logistic回归评估rs 1229984、rs671、rs1329149与结直肠癌转移风险的关系.结果 体重指数(BMI)与ADH1Brs1229984在结直肠癌发生中存在相乘交互作用(OR=1.720,95%CI:1.038~2.848,ORadj=1.785,95%CI:1.061~ 3.002);曾经或现在吸烟与ADH1B(rs1229984)的基因多态性在结直肠癌发生中存在交互作用,经调整性别、年龄和饮酒后,该交互作用消失(OR=0.597,95%CI:0.387~ 0.921,ORadj=0.922,95%CI:0.509~ 1.669);rs 1229984、rs671、rs1329149与结直肠癌的转移风险无关.结论 超重(BMI≥25 kg/m2)且携带ADH1B rs1229984 G易感等位基因可能增加结直肠癌发生的危险性,rs 1229984、rs671、rs1329149与结直肠癌的转移无关.
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Key words
Colorectal cancer,Gene-environment interaction,Gene-gene interaction,Caseonly study
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