Truncated norzoanthamine exhibiting similar collagen protection activity, toward a promising anti-osteoporotic drug.
Bioorganic & Medicinal Chemistry Letters(2014)
摘要
The marine alkaloid, norzoanthamine, is considered to be a promising drug for osteoporosis treatment. Due to its rarity and complicated structure, a practical supply method must be developed. Here, we designed a truncated norzoanthamine, which has two-thirds of the original structure, and found that it exhibited similar collagen protection activity.
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关键词
Alkaloid,Norzoanthamine,Osteoporosis,Collagen
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