Synthesis, characterization, antitumor activity and safety testing of novel polyphosphoesters bearing anthracene-derived aminophosphonate units.

I Kraicheva,E Vodenicharova,S Shenkov,E Tashev,T Tosheva,I Tsacheva,A Kril,M Topashka-Ancheva,A Georgieva,I Iliev,I Vladov,Ts Gerasimova,K Troev

Bioorganic & Medicinal Chemistry（2014）

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摘要

Novel polyphosphoesters containing anthracene-derived aminophosphonate units were synthesized and tested for antitumor activity and safety. The polymers are promising as new antiproliferative agents for treatment of breast and liver neoplasms.

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关键词

Polyphosphoesters,Aminophosphonic acids,NMR,Antitumor activity,Cytotoxicity,Genotoxicity

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