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Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus.

Salim Sharopov,Rongqing Chen,Haiyan Sun,Sergei N Kolbaev,Sergei Kirischuk,Heiko J Luhmann,Werner Kilb

Epilepsy Research（2014）

Cited 5|Views9
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Abstract
•Inhibition of GAT-1 exhibited only a minor anticonvulsive effect.•Blockade of GAT-2/3 had no anticonvulsive effect, but prolonged spontaneous GABAergic postsynaptic currents.•Combined inhibition of GAT-1 and GAT-2/3 induced a substantial anticonvulsive effect.•We conclude that GAT-1 and GAT-2/3 are functional in the immature hippocampus and act synergistically.
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Key words
Field potential recording,Development,Epilepsy,Seizure,Tiagabine
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