C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells
NATURE(2013)
Abstract
pulse of C/EBPα followed by overexpression of the transcription factors Oct4, Sox2, Klf4 and Myc leads to fast and very efficient reprogramming of B cell precursors to induced pluripotent stem cells; C/EBPα facilitates transient chromatin accessibility and accelerates expression of pluripotency genes through a mechanism that involves activation of the Tet2 enzyme.
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Key words
Induced pluripotent stem cells,Science,Humanities and Social Sciences,multidisciplinary
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