Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells

Bruno Di Stefano,Jose Luis Sardina,Chris van Oevelen,Samuel Collombet,Eric M. Kallin,Guillermo P. Vicent,Jun Lu,Denis Thieffry,Miguel Beato,Thomas Graf

NATURE（2013）

Cited 241|Views25
No score
Abstract
pulse of C/EBPα followed by overexpression of the transcription factors Oct4, Sox2, Klf4 and Myc leads to fast and very efficient reprogramming of B cell precursors to induced pluripotent stem cells; C/EBPα facilitates transient chromatin accessibility and accelerates expression of pluripotency genes through a mechanism that involves activation of the Tet2 enzyme.
More
Translated text
Key words
Induced pluripotent stem cells,Science,Humanities and Social Sciences,multidisciplinary
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined