A mucosal adjuvant for the inactivated poliovirus vaccine.

Benjamin P Steil,Patricia Jorquera,Janny Westdijk,Wilfried A M Bakker,Robert E Johnston,Mario Barro

Vaccine（2014）

Cited 16|Views15

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Abstract

•GVI 3000 adjuvant increased the potency of IPV in mice.•Systemic and mucosal immune responses to IPV were increased in mice.•IPV+GVI3000 delivered at a non-mucosal site still induced mucosal immunity.•GVI3000 increased the potency of IPV in rats by up to 23-fold.

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Key words

Inactivated poliovirus vaccine,Adjuvant,Mucosal immunity,Alphavirus

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