Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor.

Yongqi Deng,Gerald W Shipps,Lianyun Zhao,M Arshad Siddiqui,Janeta Popovici-Muller,Patrick J Curran,Jose S Duca,Alan W Hruza,Thierry O Fischmann,Vincent S Madison,Rumin Zhang,Charles W McNemar,Todd W Mayhood,Rosalinda Syto,Allen Annis,Paul Kirschmeier,Emma M Lees,David A Parry,William T Windsor

Bioorganic & Medicinal Chemistry Letters（2014）

引用 17|浏览11

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摘要

Compound 2 has been discovered that both disrupt cyclin dependent 2 (CDK2) interaction with its cyclin A subunit and act as ATP competitive inhibitors.

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关键词

Kinases,Tumor,CDK2,Modulator,High throughput screening

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