Adaptation of standard method of experimental burn injury for phagobioderm investigation]

The experimental study of thermal injury requires the use of different animal models in order to reproduce physiopathological conditions. It is described an experimental burn model using rats which allows to study different degrees of thermal damage. The described experimental burn model is comparable, reproducible by other researchers, reliable in results, simple in performance and low in cost. With this experimental model we have evaluated effects of skin burn treatment by Phagobioderm in rats. This was impossible to do by means of other experimental burn models, because they have not given possibility to investigate precisely the local histological reaction caused by treatment of burns with polymer films (in our case Phagobioderm). In our estimation, present modification of experimental model will be very useful and makes it possible to extend animal experimentation in the field of burns to units, which are not specialized and have only limited resources.