Bixin protects hepatocytes against 1,2-dimethylhydrazine-induced genotoxicity but does not suppress DNA damage and pre-neoplastic lesions in the colon of Wistar rats.

Pollyanna Francielli de Oliveira,Kelly Jacqueline Barbosa de Andrade,Marcela Cristina Ferreira Paula,Nathália Oliveira Acésio,Thais da Silva Moraes,Priscilla Scalon Freitas Borges,Gustavo Rafael Mazzaron Barcelos,Denise Crispim Tavares

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2014）

Cited 7|Views2

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Abstract

•Bixin has no genotoxic effect in liver and colon cells by comet assay.•Bixin significantly reduced the DNA damage in hepatocytes.•Bixin not reduce the frequency of DNA damage in colon cells.•Bixin not suppress the formation of pre-neoplastic lesions in colon.

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Key words

Bixin,Bixa orellana,Aberrant crypt foci,Comet assay

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