Evidence for an internal and functional circadian clock in rat pituitary cells.

Denis Becquet,Bénédicte Boyer,Ramahefarizo Rasolonjanahary,Thierry Brue,Séverine Guillen,Mathias Moreno,Jean-Louis Franc,Anne-Marie François-Bellan

Molecular and Cellular Endocrinology（2014）

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摘要

•Pituitary cells house a functional circadian oscillator.•A dominant negative mutant of BMAL1 disrupts the circadian oscillator in GH4C1.•Disruption of the circadian oscillator abolishes rhythmic gene expression in GH4C1.

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关键词

Pituitary cells,GH4C1 cells,Core-clock genes,Clock-controlled genes,Circadian oscillator

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