Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells.

Sabine Rütti,Caroline Arous,Alexandra C Nica,Makoto Kanzaki,Philippe A Halban,Karim Bouzakri

FEBS Letters（2014）

引用 16|浏览9

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摘要

•TBC1D1 is expressed in human and rat beta-cells.•TBC1D1 is phosphorylated in response to glucose.•Knockdown of TBC1D1 resulted in increased basal and glucose-stimulated insulin release.•TBC1D1 is involved in beta-cell proliferation but not in apoptosis.

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关键词

Beta-cell,TBC1D1,Proliferation,Apoptosis,Glucose response

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