Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation.

•A novel functional role of BCAR3 in insulin signaling is proposed.•Microinjection of inhibitory BCAR3 materials blocks insulin-stimulated DNA synthesis and membrane ruffling.•BCAR3 is not involved in GLUT4 translocation.•BCAR3 differentially regulates the signaling pathway of insulin and IGF-1 leading to DNA synthesis.•The SH2 domain of BCAR3 plays an important role in the insulin pathway.