Gene expressions changes in bronchial epithelial cells: markers for respiratory sensitizers and exploration of the NRF2 pathway.

Sylvie Remy,Sandra Verstraelen,Rosette Van Den Heuvel,Inge Nelissen,Nathalie Lambrechts,Jef Hooyberghs,Greet Schoeters

Toxicology in Vitro（2014）

引用 11|浏览3

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摘要

•Whole human transcriptome profile of BEAS-2B cells exposed to respiratory sensitizers, skin sensitizers, and respiratory irritants.•Potential biomarkers for identification of respiratory sensitizing chemicals.•NRF2-mediated oxidative stress response is a common toxicity pathway for small chemical entities.

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关键词

Respiratory sensitization,In vitro,BEAS-2B cell line,Transcriptomics,Gene expression markers

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