Hagfish C1q: its unique binding property.

Tomokazu Yamaguchi,Kazufumi Takamune,Masakazu Kondo,Yukinori Takahashi,Yoko Kato-Unoki,Miki Nakao,Naomi Sano,Tamotsu Fujii

Developmental & Comparative Immunology（2014）

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摘要

•We identified a homologue of mammalian C1q in hagfish serum.•Hagfish C1q bound to various microbes in a Ca2+ dependent manner.•Hagfish C1q bound to peptidoglycan in a Ca2+ dependent manner.•Hagfish C1q bound to agarobiose but not to monosaccharide.•High density of agarobiose was necessary for stable binding of Hagfish C1q.

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关键词

Pattern-recognition molecule,C1q,Innate immunity,Complement system,Eptatretus burgeri

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