Sick sinus syndrome possibly due to lopinavir-ritonavir: report of two cases]
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases(2013)
摘要
We describe herein two cases of sick sinus syndrome possibly due to lopinavir-ritonavir in HIV-infected individuals. The heart rate dropped to 30 to 40 beats per minute in both cases, but patients remained asymptomatic and recovered promptly after discontinuation of lopinavir-ritonavir. The time until onset varied; one patient developed bradyarrhythmia 9 days after the initial dose, and another 4 hours after. Since lopinavir-ritonavir is a frequently used antiretroviral agent, clinicians must be aware of this potentially lethal adverse effect.
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关键词
sick sinus syndrome,lopinavir-ritonavir
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