Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65

Two new meroterpenoids, arisugacins I ( 1 ) and J ( 2 ), together with five known meroterpenoids including arisugacin B ( 3 ), arisugacin F ( 4 ), arisugacin G ( 5 ), territrem B ( 6 ) and territrem C ( 7 ) were isolated from an endophytic fungus Penicillium sp. SXH-65. Their structures were determined by extensive spectroscopic experiments and comparison with literature data. Their cytotoxicities were evaluated against Hela, HL-60 and K562 cell lines, and only 3 and 4 exhibited weak cytotoxicities against Hela, HL-60 and K562 cell lines with IC 50 values ranging from 24 to 60 μM.