Discovery of the First M5-selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9B-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1h-imidazo[2,1-a]isoindol-5(9bh)-one (ML375).
Journal of Medicinal Chemistry（2013）
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