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Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

Kimberly A Hartwell,Peter G Miller,Siddhartha Mukherjee,Alissa R Kahn,Alison L Stewart,David J Logan,Joseph M Negri,Mildred Duvet,Marcus Järås,Rishi Puram,Vlado Dancik,Fatima Al-Shahrour,Thomas Kindler,Zuzana Tothova,Shrikanta Chattopadhyay,Thomas Hasaka,Rajiv Narayan,Mingji Dai,Christina Huang,Sebastian Shterental,Lisa P Chu,J Erika Haydu,Jae Hung Shieh,David P Steensma,Benito Munoz,Joshua A Bittker,Alykhan F Shamji,Paul A Clemons,Nicola J Tolliday,Anne E Carpenter,D Gary Gilliland,Andrew M Stern,Malcolm A S Moore,David T Scadden,Stuart L Schreiber,Benjamin L Ebert,Todd R Golub

Nature chemical biology（2013）

Cited 124|Views40
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Abstract
High-throughput screening systems that better mimic the physiological complexity of diseased tissues may aid the discovery of more efficacious compounds. A co-culture system that mimics the microenvironment of leukemia stem cells (LSCs) in bone marrow enables the discovery of compounds, including lovastatin, that selectively kill LSCs.
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nature chemical biology, science
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