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Heart field origin of great vessel precursors relies on nkx2.5 -mediated vasculogenesis

Noëlle Paffett-Lugassy,Reena Singh,Kathleen R. Nevis,Burcu Guner-Ataman,Evan O’Loughlin,Leila Jahangiri,Richard P. Harvey,C. Geoffrey Burns,Caroline E. Burns

NATURE CELL BIOLOGY（2013）

Cited 61|Views5
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Abstract
During vertebrate embryogenesis, the pharyngeal arch arteries (PAA) connect segments of the primitive circulation. Burns and colleagues show that Nkx2.5 + heart precursors from the lateral plate mesoderm surprisingly give rise to the PAA angioblasts, and that Nkx2.5 is required for PAA development.
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Key words
Angiogenesis,Embryology,Heart stem cells,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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