Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.

Taisuke Hoshi,Tohru Tezuka,Kazumasa Yokoyama,Shun-ichiro Iemura,Tohru Natsume,Yuji Yamanashi

FEBS Letters（2013）

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摘要

•Mesdc2 binds to Lrp4.•Mesdc2 is essential for glycosylation and cell-surface expression of Lrp4.•Mesdc2 plays a key role in MuSK-dependent postsynaptic specialization in myotubes.

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关键词

ACh,AChR,Btx,CMS,Dok-7,DPAGT1,GFPT1,LC–MS/MS,Lrp4,Mesdc2,MuSK,NMJ,TM,WCL

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