In vitro evaluation of TLR4 agonist activity: formulation effects.

Ayesha Misquith,H W Millie Fung,Quinton M Dowling,Jeffrey A Guderian,Thomas S Vedvick,Christopher B Fox

Colloids and Surfaces B: Biointerfaces（2014）

Cited 45|Views5

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Abstract

•TLR4 ligands are promising vaccine adjuvant candidates.•In vitro assays (e.g. macrophage cytokine production) evaluate adjuvant activity.•Different formulations of the same TLR4 ligand modulate its in vitro bioactivity.

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Key words

Vaccine adjuvant formulation,TLR4 agonist,In vitro bioactivity,Particle size,Physicochemical characterization,Glucopyranosyl lipid adjuvant

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