Effect of atrial natriuretic peptide on reactive oxygen species-induced by hydrogen peroxide in THP-1 monocytes: role in cell growth, migration and cytokine release.

•ANP effect on H2O2-induced ROS generation, cell proliferation, migration and cytokine release was detected in monocytes.•ANP was able to increase the H2O2-dependent ROS production partly by the involvement of the NADPH oxidase.•ANP was able to stimulate cell migration and decrease THP-1 proliferation.•ANP plays a role in the IL-9, TNF-α, MIP-1α release whereas no effect was observed for IL-6 and IL-1β.•Our results support the view that ANP can play a key role during the inflammatory process.