Mucosa-Associated Lymphoid Tissue Lymphoma Of The Extrahepatic Bile Duct

Mucosa-associated lymphoid. tissue lymphoma of the, extrahepatic, bile duct has not yet, been reported. Much more common than this is secondary involvement of the extralrepatic bile duct in cases of disseminated lymphoma. A 59-year-old-man manifesting jaundice was referred to our hospital. PTC revealed an extrahepatic bile duct stenosis from the hilum to the lower part of the choledochus. On the operative specimen, we examined L26/CD20, Bcl-2, UCHL-1/CD45RO, cyclin D1 and p53. Histologically, follicular colonization, centrocyte-like cells and lymphoepithelial. Jesion was observed. Tumor cells were positive for L26/CD20 and Bcl-2 and were negative for intracytoplasmic immunoglobulins, UCHL-I/CD45RO, cyclin D1 and p53. Pathological diagnosis was mucosa-associated lymphoid tissue lymphoma of the extrahepatic bile duct. The authors present herein the first case of mucosa-associated lymphoid tissue lymphoma, of the extrahepatic bile. duct. It was very difficult to distinguish from hilar cholangiocarcinoma clinically. Only incomplete stenosis of the bile duct and 1-8-F fluoro-2-deoxyglucose positron emission tomography (FDG-PET) could suggest this unusual clinical entity. Tumor cells were positive for L26/CD20 and Bcl-2 and were negative for intracytoplasmic immunoglobulins, UCHL-1/CD45RO, cyclin D1 and p53. Pathological diagnosis was mucosa-associated lymphoid tissue lymphoma of the extrahepatic bile duct. The authors present herein the first case of mucosa-associated lymphoid tissue lymphoma, of the extra-bile. duct. It was very difficult to distinguish from hilar cholangiocarcinoma clinically. Only stenosis of the bile duct and 1-8-F fluoro-2-deoxyglucose positron emission tomography (FDG-PET) could suggest this unusual clinical entity.