Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach.

Michael P Dwyer,Kartik Keertikar,Kamil Paruch,Carmen Alvarez,Marc Labroli,Cory Poker,Thierry O Fischmann,Rosemary Mayer-Ezell,Richard Bond,Yan Wang,Rita Azevedo,Timothy J Guzi

Bioorganic & Medicinal Chemistry Letters（2013）

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摘要

The synthesis and SAR development of a class of pyrazolo[1,5-a]pyrimidine-based Pim kinase inhibitors are detailed from an early HTS hit to a pan–Pim inhibitor such as 11j.

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关键词

Pan–Pim kinase,pyrazolo[1,5-a]pyrimidine

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