Regulation of monocyte/macrophage function by factor VII activating protease (FSAP).

Mariana S Parahuleva,Robert Maj,Hans Hölschermann,Behnoush Parviz,Yaser Abdallah,Ali Erdogan,Harald Tillmanns,Sandip M Kanse

Atherosclerosis（2013）

引用 17|浏览10

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摘要

•We investigate the FSAP induced IκappaB-dependent NF-κappaB activation.•FSAP enhances expression of pro-inflammatory cytokines and matrix metalloproteinases, and up-regulation of adhesion molecules.•FSAP increases monocytes adhesion and transendothelial migration in a beta2 integrin dependent manner.

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关键词

Atherosclerosis,FSAP,Monocytes/macrophages,NF-κB,Vascular inflammation

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