Long-term use of statins reduces the risk of hospitalization for dementia.

Giovanni Corrao,Buthaina Ibrahim,Federica Nicotra,Antonella Zambon,Luca Merlino,Thea Scognamiglio Pasini,Alberico L Catapano,Giuseppe Mancia

Atherosclerosis（2013）

Cited 37|Views6

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Abstract

•We performed a nested case-control study linking healthcare utilization databases.•We investigated the effect of the duration of statins on the risk of dementia.•Long-term use of statins seems effective for the prevention of dementia.•Simvastatin and atorvastatin were both associated with a reduced risk of dementia.•No evidence was observed for fluvastatin and pravastatin.

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Key words

Alzheimer's disease,Dementia,Healthcare Utilization Database,Lipid-lowering agents,Monte-Carlo sensitivity analysis,Record linkage,Statins,Rule-out sensitivity analysis,Unmeasured confounders

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