Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction.

Eiko N Minakawa,Hodaka Yamakado,Atsushi Tanaka,Kengo Uemura,Shunichi Takeda,Ryosuke Takahashi

Neuroscience Research（2013）

Cited 6|Views4

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Abstract

•A novel model of Parkinson's disease was created using DT40, a chicken B cell line.•Targeted gene disruption of DJ-1 in DT40 was utilized to generate this model.F•These cells exhibited phenotypes compatible with DJ-1-deficient mammalian cells.•Gene-modified DT40 cells would be a relevant model of Parkinson's disease.

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Key words

PD,ROS,H2O2,carboxy-H2DCFDA,AV,PI,TMRE,CCCP,MMP

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