A Meta-Analysis Of The Association Of G915c, G800a, C509t Gene Polymorphism Of Transforming Growth Factor-Beta 1 With Diabetic Nephropathy Risk

This meta-analysis was conducted to evaluate the association of transforming growth factor-beta 1 (TGF-beta 1) G915C, G800A, C509T gene polymorphism with the risk of diabetic nephropathy (DN). The association literatures were identified from PubMed, Cochrane Library, and CBM-disc (China Biological Medicine Database) on March 1, 2013, and eligible reports were recruited and synthesized. Seven reports were recruited into this meta-analysis for the association of TGF-beta 1 G800A, C509T, G915C gene polymorphism with DN risk. GG genotype, CC genotype, and C allele of TGF-beta 1 G915C were not associated with the DN risk (GG: OR = 0.84, 95% CI: 0.62-1.14, p = 0.27; CC: OR = 1.05, 95% CI: 0.50-2.22, p = 0.90; C allele: OR = 1.16, 95% CI: 0.88-1.51, p = 0.29). Furthermore, TGF-beta 1 G800A, C509T gene polymorphism was not associated with the DN risk. In conclusion, TGF-beta 1 G915C, G800A, and C509T gene polymorphism are not associated with the DN risk. However, more studies should be performed to confirm this relationship in the future.