A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.

Zachary L Bergeron,Joycelyn B Chun,Margaret R Baker,David W Sandall,Steve Peigneur,Peter Y C Yu,Parashar Thapa,Jeffrey W Milisen,Jan Tytgat,Bruce G Livett,Jon-Paul Bingham

Peptides（2013）

Cited 16|Views19

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Abstract

•Single Cone snail analysis shows m/z continuity in duct, milk and radula extracts.•Geographic specimen analysis shows peptide diversity in the milked venoms.•α-Conotoxin TxIC represents a highly post-translationally modified conotoxin.•Post-translational modifications influence biological and phylogenetic selectivity.

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Key words

αα,CH3CN,Acm,API,DHB,cDNA,CHCA,CID,DCM,DIEA,DMF,DV,ESMS,FDA,Fmoc,Fmoc-Asn(Trt)-OH,Fmoc-Asp(OtBu)-OH,Fmoc-Arg(Pbf)-OH,Fmoc-Cys(Acm)-OH,Fmoc-Cys(Trt)-OH,Fmoc-Gla(otBu)2-OH,Fmoc-Gln(Trt)-OH,Fmoc-His(Trt)-OH,Fmoc-Hyp(tBu)-OH,GBR,(Gla),HCTU,IND,MALDI-MS,MALDI-TOF-(TOF)-MS,Mr,mRNA,MS,MV,m/z,nAChR,PCR,PSD,PTM,RE,RV,RP-HPLC,Rt,SEM,SPPS,TCEP,TFA,UV,TIPS

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