Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats

International Journal of Developmental Neuroscience(2013)

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摘要
•A moderate dose of VPA has long-term effects on social interaction behaviors.•Behavioral effects are opposite of those described after a high dose of VPA.•Transcriptomic analysis identified some intriguing differences.•Differential whole-genes and individual exons expression were identified.
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aa,AA,ANCOVA,ANOVA,CREB,CREBBP,CV,DNA,G,GABA,HDAC,HDACi,ID,i.p.,IUTs,mg/kg,mRNA,OFC,P,P. C.,RNA,RTS,VPA
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