Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter.

Keiji Matsui,Kasumi Oda,Shumpei Mizuta,Ruri Ishino,Norinaga Urahama,Natsumi Hasegawa,Robert G Roeder,Mitsuhiro Ito

Biochemical and Biophysical Research Communications（2013）

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摘要

•MED1 is a bona fide T3-dependent coactivator on TSHB promoter.•Mice with LxxLL-mutant MED1 have attenuated TSHβ mRNA and thyroid hormone levels.•MED1 activates TSHB promoter T3-dependently in cultured cells.•T3-dependent MED1 action is enhanced when SRC1/SRC2 or HDAC2 is downregulated.•MED1 is also a T3-independent GATA2/Pit1 coactivator on TSHB promoter.

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关键词

Mediator,MED1,Negative TR-responsive element,TSHβ gene promoter,TRβ

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