Estradiol and striatal dopamine receptor antagonism influence memory system bias in the female rat

•Systemic dopamine D1 and D2 receptor antagonists affect memory system bias in low but not high estrogen rats.•Here we injected D1 and D2 antagonists directly into the dorsal or ventral striatum.•Dorsal, but not ventral, striatal D1 antagonism altered memory system bias.•Systemic D2 antagonism likely affecting memory systems in a different brain area.