Aryl hydrocarbon receptor-dependent cell cycle arrest in isolated mouse oval cells

Dagmar Faust, Stephanie Kletting, Elke Ueberham,Cornelia Dietrich

Toxicology Letters（2013）

引用 23|浏览4

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摘要

•Oval cells derived from mouse liver show an intact canonical AhR signaling.•TCDD induces cell cycle arrest in mouse oval cells.•TCDD-induced cell cycle arrest is mediated by the aryl hydrocarbon receptor.•TCDD-treatment leads to downregulation of cyclin D1 and A and upregulation of p27.

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关键词

Mouse oval cells,TCDD,Aryl hydrocarbon receptor,Cell cycle

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