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Elevated guanylate cyclase and cyclic-guanosine monophosphate-dependent protein kinase levels in nasal mucosae of antigen-challenged rats.

Hiroyasu Sakai,Tatsuya Hara,Kenji Todoroki,Yuma Igarashi,Miwa Misawa,Minoru Narita,Yoshihiko Chiba

Microvascular Research（2013）

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Abstract
•cGMP-induced venodilatation was promoted in nasal mucosae of antigen-challenged rats.•Expressions of sGC/PKG were increased in nasal mucosae of antigen-challenged rats.•Augmented cGMP/PKG may enhance venodilatation in nasal mucosae of allergic rhinitis.
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Key words
guanylate cyclase,nasal mucosae,cyclic-guanosine,monophosphate-dependent,antigen-challenged
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