Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy.
Clinical ophthalmology (Auckland, N.Z.)(2013)
摘要
BACKGROUND:"Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA.
AIM:The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls.
METHODS:This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay.
RESULTS:The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20).
CONCLUSION:This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.
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