A Multicenter Phase II Study of Docetaxel 60 mg/m 2 as First-Line Chemotherapy in Patients with Advanced or Recurrent Breast Cancer

Purpose Docetaxel is an active agent as first-line chemotherapy in patients with advanced breast cancer at a dosage of 100 mg/m 2 . However, the efficacy of this agent as a first-line drug when used at a lower dosage is unclear. This study was performed to evaluate the clinical efficacy and safety of 60 mg/m 2 docetaxel for the treatment of breast cancer. Patients and Methods This study enrolled 23 patients with advanced and/or metastatic breast cancer, who had not been treated with an anthracycline or taxane previously. Treatment with docetaxel was continued in patients showing a response until there was evidence of disease progression or unacceptable toxicity. Results Among 20 fully evaluated patients, the overall response rate was 50.0% and the median time to progression was 31 weeks. The most commonly observed adverse events were neutropenia (78.2%) and fatigue (60.9%). Fluid retention occurred in only 8.7% of the patients. Adverse events did not cause discontinuation of the treatment. Conclusion Docetaxel achieved good disease control with mild adverse events in first-line treatment at a dosage of 60 mg/m 2 .