ABO incompatibility and newborn haemolytic disease: about two cases with major erythroblastosis

Two cases of newborn haemolytic disease because of ABO incompatibility are reported. In both cases, blood erythroblastosis exceeded 300 per 100 leukocytes at birth. Both newborns developed early jaundice and one presented with anaemia. Intensive phototherapy begun soon after birth was an effective treatment. The diagnosis of newborn jaundice and the pathophysiological basis of haemolytic disease because of ABO incompatibility are discussed.