Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer.

Background: Hypoxia inducible factor-1alpha (HIF-1alpha) has been correlated with unfavorable prognosis in several cancers. The aim of this study was to investigate the impact of HIF-1alpha expression on clinicopathological factors and to clarify whether or not HIF-1alpha is correlated with angiogenesis and mutation of p53 in pancreatic cancer. Materials and Methods: Using immunohistochemical methods, we examined the expression of HIF-1alpha, vascular endothelial growth factor (VEGF), p53 and intratumoral microvessel density (1MD) in 55 cases of primary pancreatic cancer. Results: Immunohistochemical studies showed that 40.0% cases were positive and the status of HIF-1a was significantly correlated with metastatic status (p=0.048), VEGF expression (p=0.026) and IMD (p=0.0061). HIF-1a is significantly related to prognosis in pancreatic cancer. Conclusion: Our data demonstrate that pancreatic cancer widely expresses HIF-1alpha, which contributes to angiogenesis and progression. Therefore, assessment of HIF-1alpha expression might be useful for predicting the prognosis of pancreatic cancer patients.