A case of multiple liver metastases of colon cancer with PyNPase-positive successfully treated with 5'-DFUR]
Gan to kagaku ryoho. Cancer & chemotherapy(2003)
摘要
A 75-year-old man was diagnosed with transverse colon cancer. We therefore performed a transverse colectomy. Diagnosis of multiple liver metastases was made by intraoperative palpation, core needle biopsy and postoperative abdominal CT scan. 5'-deoxy-5-fluorouridine (5'-DFUR) 800 mg/day was administered orally after the surgery. After 2 months of administration, an abdominal CT scan showed the metastatic lesions of liver were reduced. After 8 months, an abdominal CT scan showed no evidence of liver metastases. Pyrimidine nucleoside phosphorylase (PyNPase), an enzyme that converts 5'-DFUR to 5-FU, has an important role in the expression of the anti-tumor activity of 5'-DFUR. Primary specimens of this case were regarded as PyNPase-positive. We think that administration of 5'-DFUR may be a useful treatment for advanced colon cancer that is PyNPase-positive.
更多查看译文
关键词
multiple liver metastases,colon cancer,pynpase-positive
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要