Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis.

Kazutoshi Saito,Yuko Nukada,Osamu Takenouchi,Masaaki Miyazawa,Hitoshi Sakaguchi,Naohiro Nishiyama

Toxicology in Vitro（2013）

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摘要

•Gene expression profile was examined in RhE model.•Five cellular stress related genes were significantly upregulated by DNFB and OXA.•Predictive performance of ATF3 gene displayed 100% accuracy to animal testing.•Tested four pre-/pro-haptens were correctly predicted by ATF3 and DNAJB4 genes.•A RhE-based assay could detect skin sensitizing potential of chemicals.

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ACD,ADH,AOO,ATF3,BKC,CA,CinA,CYP,DAVID,DCs,DNAJB4,DNCB,DNFB,ECVAM,EpiSensA,ER,GCLM,GO,GSH,HSPA6,HSPH1,IEU,IL,KCs,LA,LLNA,2-MBT,MDBGN,MTT,4-NBB,OXA,PPD,RhE,ROS,SA,SLS,TMTD,TNF

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