Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity.

Timothy P Shiau,Eddy Low,Bum Kim,Eric D Turtle,Charles Francavilla,Donogh J R O'Mahony,Lisa Friedman,Louisa D'Lima,Andreas Jekle,Dmitri Debabov,Meghan Zuck,Nichole J Alvarez,Mark Anderson,Ramin Ron Najafi,Rakesh K Jain

Bioorganic & Medicinal Chemistry Letters（2013）

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摘要

Polyol-solubilized 3-(dichloroamino)-3-methylbutylsulfones 1a–m and sulfonamides 2a–b show fast-acting, broad spectrum antimicrobial activity against bacterial and viral pathogens as tested by 1-h MBC’s against E. coli and S. aureus, and 1-h IC50’s against Ad5 and HSV-1.

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关键词

Bactericidal,Virucidal,Bacteria,Virus,Conjunctivitis,Chloroamines

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