CDR-restricted Engineering of Native Human Scfvs Creates Highly Stable and Soluble Bifunctional Antibodies for Subcutaneous Delivery.
Brian J. Fennell,Barry McDonnell,Amy Sze Pui Tam, Lijun Chang,John Steven,Ian D. Broadbent,Huilan Gao,Elizabeth Kieras,Jennifer Alley,Deborah Luxenberg,Jason Edmonds,Lori J. Fitz,Wenyan Miao,Matthew J. Whitters,Quintus G. Medley,Yongjing J. Guo,Alfredo Darmanin-Sheehan,Benedicte Autin,Deirdre Ni Shuilleabhain,Emma Cummins,Amy King,Mark R. H. Krebs,Christopher Grace,Timothy P. Hickling, Angela Boisvert,Xiaotian Zhong,Matthew McKenna,Christopher Francis,Stephane Olland,Laird Bloom,Janet Paulsen,Will Somers,Allan Jensen,Laura Lin,William J. J. Finlay,Orla Cunningham mAbs（2013）
Key words
affinity optimization,phage display,thermal stability,high concentration formulation,bispecific scFv-Fc-scFv
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