GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

Catherine Frelin,Robert Herrington,Salima Janmohamed,Mary Barbara,Gary Tran,Christopher J Paige,Patricia Benveniste,Juan-Carlos Zuñiga-Pflücker,Abdallah Souabni,Meinrad Busslinger,Norman N Iscove

NATURE IMMUNOLOGY（2013）

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摘要

lthough GATA-3 is expressed in hematopoietic stem cells, its function there remains unclear. Iscove and colleagues show that GATA-3 inhibits the self-renewal potential of long-term hematopoietic stem cells downstream of p38 signaling.

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nature immunology, science

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