Surface modification of biomaterials for conjugation with human fetal osteoblasts.
CHIMIA(2013)
摘要
Surface functionalization of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
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关键词
Cell adhesions,Copper-free click reaction,Functionalized biomaterials,Human fetal osteoblasts
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