Discovery of Novel (1S)-(−)-verbenone Derivatives with Anti-Oxidant and Anti-Ischemic Effects
Bioorganic & medicinal chemistry letters(2013)
Abstract
A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress. (C) 2013 Elsevier Ltd. All rights reserved.
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Key words
Cerebral ischemia,Anti-oxidant activity,Anti-excitotoxic activity,Anti-ischemic activity,Verbenone
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